These findings suggest that bupropion's effect on REM latency and its AD action might be linked, possibly via dopamine (D(2)) receptor-mediated effects, or by noradrenergic mechanism(s). Moreover, the REM latency change in response to bupropion challenge correlated with change in depression ratings as a result of treatment. I also had this issue with WB and was told to up my Ativan at night. Taking it as early as you can one dose may help. As one of the side effects that may not go away is increased anxiety 'jetters'. If you have a sleep disorder or anxiety this may not be the med for you. Responders showed an increase in REM latency following bupropion challenge, whereas non-responders showed a decrease. Like everyone said Wellbutrin is known for it's 'jetters'. However, a statistically significant relationship was found between latency to the onset of rapid eye movement (REM) sleep following a single dose of bupropion and clinical response to treatment with bupropion. No relationship was observed between baseline EEG sleep measures and response to treatment with bupropion. Bupropion hydrochloride is rarely tried in the insomnia community. The participants then received open-label treatment with bupropion SR for about 8 weeks. Wellbutrin is a brand name for the drug bupropion hydrochloride. Baseline EEG sleep and the EEG sleep responses to placebo (baseline sleep) and a single dose of bupropion SR (150 mg, PO) were measured using a randomized, double-blind, crossover design. Subjects were studied twice for 2 consecutive nights, with each 2-night session approximately 1 week apart. According to the FDA, Wellbutrin can cause anxiety-related side effects in some people. Twenty patients with unipolar major depressive disorder received EEG sleep assessments prior to treatment. To avoid or limit the risk of insomnia, do not administer doses at bedtime. To examine the effect of bupropion sustained release (SR) (Wellbutrin SR) on sleep macroarchitecture, and to assess whether the observed electroencephalographic (EEG) sleep changes in response to a single dose of bupropion are associated with treatment response to the AD. A change to the treatment regimen or discontinuation of bupropion may be. However, newer AD agents, which appear to have different effects on sleep, have not been evaluated systematically for their usefulness in predicting treatment response. The effects of antidepressant (AD) drugs on sleep in depressed patients and their relationship to AD response have been investigated previously.
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